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Article

Overlapping activation-induced cytidine deaminase hotspot motifs in Ig class-switch recombination.

Proceedings of the National Academy of Sciences of the United States of America - 12 Jul 2011

Han Li, Masani Shahnaz, Yu Kefei

Abstract excerpt

Ig class-switch recombination (CSR) is directed by the long and repetitive switch regions and requires activation-induced cytidine deaminase (AID). One of the conserved switch-region sequence motifs (AGCT) is a preferred site for AID-mediated DNA-cytosine deamination. By using somatic gene targeting and recombinase-mediated cassette exchange, we established a cell line-based CSR assay that allows manipulation of...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Identifiers

PMID: 21709240
DOI: 10.1073/pnas.1018726108
PMCID: PMC3136278

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