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Article

DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine.

The Journal of biological chemistry - 20 Feb 2004

Yu Kefei, Huang Feng-Ting, Lieber Michael R

Abstract excerpt

Activation-induced deaminase (AID) is required for both immunoglobulin class switch recombination and somatic hypermutation. AID is known to deaminate cytidines in single-stranded DNA, but the relationship of this step to the class switch or somatic hypermutation processes is not entirely clear....

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Identifiers

PMID: 14645244
DOI: 10.1074/jbc.M311616200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14645244-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine.PMID 14645244Read ↗

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Mutations in human AID differentially affect its ability to deaminate cytidine and 5-methylcytidine in ssDNA substrates in vitro.Semantic proximity Read ↗

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