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Article

Enhanced pathogenicity of diabetogenic T cells escaping a non-MHC gene-controlled near death experience.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2004

Choisy-Rossi Caroline-Morgane, Holl Thomas M, Pierce Melissa A, Chapman Harold D, Serreze David V

Abstract excerpt

For unknown reasons, the common MHC class I variants encoded by the H2g7 haplotype (Kd, Db) aberrantly elicit autoreactive CD8 T cell responses essential to type 1 diabetes development when expressed in NOD mice, but not other strains. In this study, we show that interactive non-MHC genes allow a NOD-derived diabetogenic CD8 T cell clonotype (AI4) to be negatively selected at far greater efficiency in C57BL/6...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15356126
DOI: 10.4049/jimmunol.173.6.3791

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Enhanced pathogenicity of diabetogenic T cells escaping a non-MHC gene-controlled near death experience.PMID 15356126Read ↗

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