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Article

Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity.

The Journal of clinical investigation - 1 Sept 2003

Stratmann Thomas, Martin-Orozco Natalia, Mallet-Designe Valérie, Poirot Laurent, McGavern Dorian, Losyev Grigoriy, Dobbs Cathleen M, Oldstone Michael B A, Yoshida Kenji, Kikutani Hitoshi, Mathis Diane, Benoist Christophe, Haskins Kathryn, Teyton Luc

Abstract excerpt

To detect and characterize autoreactive T cells in diabetes-prone NOD mice, we have developed a multimeric MHC reagent with high affinity for the BDC-2.5 T cell receptor, which is reactive against a pancreatic autoantigen. A distinct population of T cells is detected in NOD mice that recognizes t...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12975475
DOI: 10.1172/JCI18337
PMCID: PMC193666

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12975475-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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