Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The diabetogenic mouse MHC class II molecule I-Ag7 is endowed with a switch that modulates TCR affinity.

The Journal of clinical investigation - 1 May 2010

Yoshida Kenji, Corper Adam L, Herro Rana, Jabri Bana, Wilson Ian A, Teyton Luc

Abstract excerpt

Genetic susceptibility to autoimmunity is frequently associated with specific MHC alleles. Diabetogenic MHC class II molecules, such as human HLA-DQ8 and mouse I-Ag7, typically have a small, uncharged amino acid residue at position 57 of their beta chain (beta57); this results in the absence of a salt bridge between beta57 and Argalpha76, which is adjacent to the P9 pocket of the peptide-binding groove. However,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Separation
Share to Diabetes Mellitus, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dimerization

Share to Histocompatibility Antigens Class II

Share to Hybridomas

Share to Molecular Conformation

Share to Receptors, Antigen, T-Cell

Share to Thymus Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 20407212
DOI: 10.1172/JCI41502
PMCID: PMC2860908

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The diabetogenic mouse MHC class II molecule I-Ag7 is endowed with a switch that modulates TCR affinity.PMID 20407212Read ↗

A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes.Semantic proximity Read ↗

Recognition of a specific self-peptide: self-MHC class II complex is critical for positive selection of thymocytes expressing the D10 TCR.Semantic proximity Read ↗

On the perils of poor editing: regulation of peptide loading by HLA-DQ and H2-A molecules associated with celiac disease and type 1 diabetes.Semantic proximity Read ↗

Position β57 of I-A g7 controls early anti-insulin responses in NOD mice, linking an MHC susceptibility allele to type 1 diabetes onsetSemantic proximity Read ↗

Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen.Semantic proximity Read ↗

A new model defines the minimal set of polymorphism in HLA-DQ and -DR that determines susceptibility and resistance to autoimmune diabetes.Semantic proximity Read ↗

Predominant occupation of the class I MHC molecule H-2Kwm7 with a single self-peptide suggests a mechanism for its diabetes-protective effect.Semantic proximity Read ↗

Conformational Plasticity of HLA-B27 Molecules Correlates Inversely With Efficiency of Negative T Cell SelectionSemantic proximity Read ↗

Critical contribution of beta chain residue 57 in peptide binding ability of both HLA-DR and -DQ molecules.Semantic proximity Read ↗

Distinguishing self from nonself: immunogenicity of the murine H47 locus is determined by a single amino acid substitution in an unusual peptide.Semantic proximity Read ↗

The P9 peptide sidechain specificity of I-Ad.Semantic proximity Read ↗

Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.