Article

Thymic self-recognition-mediated TCR signal strength modulates antigen- specific CD8 <sup>+</sup> T cell pathogenicity in non-obese diabetic mice

2024-06-12

Abstract excerpt

Our understanding of autoimmune diabetes underscores the critical involvement of CD8 + T cells recognizing islet-specific antigens. However, the influence of thymic positive selection on diabetogenic CD8 + T cell development remains unclear. Using CD5 marker representing T-cell receptor (TCR) signal strength, we illustrated that naïve CD5 hi CD8 + T cells of non-obese diabetic (NOD) mice with enhanced TCR sign...

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Literature Corpus work: 71336366-013d-5afa-8663-eab1405a0b5d
DOI: 10.1101/2024.06.10.596762

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