Article
Analysis of the role of variation of major histocompatibility complex class II expression on nonobese diabetic (NOD) peripheral T cell response.
The Journal of experimental medicine - 21 Dec 1998
Ridgway W M, Ito H, Fassò M, Yu C, Fathman C G
Abstract excerpt
The current paradigm of major histocompatibility complex (MHC) and disease association suggests that efficient binding of autoantigens by disease-associated MHC molecules leads to a T cell-mediated immune response and resultant autoimmune sequelae. The data presented below offer a different model...
Topics
- Animals
- Antigen Presentation
- Antigen-Presenting Cells
- Autoantigens
- Crosses, Genetic
- Diabetes Mellitus, Type 1
- Female
- Genotype
- Histocompatibility Antigens Class II
- Lymphocyte Activation
- Lymphoid Tissue
- Mice
- Mice, Congenic
- Mice, Inbred NOD
- Mice, Transgenic
- Peptides
- Phenotype
- Specific Pathogen-Free Organisms