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Article

Analysis of the role of variation of major histocompatibility complex class II expression on nonobese diabetic (NOD) peripheral T cell response.

The Journal of experimental medicine - 21 Dec 1998

Ridgway W M, Ito H, Fassò M, Yu C, Fathman C G

Abstract excerpt

The current paradigm of major histocompatibility complex (MHC) and disease association suggests that efficient binding of autoantigens by disease-associated MHC molecules leads to a T cell-mediated immune response and resultant autoimmune sequelae. The data presented below offer a different model for this association of MHC with autoimmune diabetes. We used several mouse lines expressing different levels of I-Ag7...

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Identifiers

PMID: 9858513
DOI: 10.1084/jem.188.12.2267
PMCID: PMC2212423

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Analysis of the role of variation of major histocompatibility complex class II expression on nonobese diabetic (NOD) peripheral T cell response.PMID 9858513Read ↗

Reduction in diabetes incidence in an I-Ag7 transgenic nonobese diabetic mouse line.Semantic proximity Read ↗

Through regulation of TCR expression levels, an Idd7 region gene(s) interactively contributes to the impaired thymic deletion of autoreactive diabetogenic CD8+ T cells in nonobese diabetic mice.Semantic proximity Read ↗

MHC class II molecules play a role in the selection of autoreactive class I-restricted CD8 T cells that are essential contributors to type 1 diabetes development in nonobese diabetic mice.Semantic proximity Read ↗

Distinct genetic control of autoimmune neuropathy and diabetes in the non-obese diabetic background.Semantic proximity Read ↗

Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity.Semantic proximity Read ↗

A hypermorphic <i>Nfkbid</i> allele represents an <i>Idd7</i> locus gene contributing to impaired thymic deletion of autoreactive diabetogenic CD8 <sup>+</sup> T-cells in NOD miceSemantic proximity Read ↗

Autoimmune syndromes in major histocompatibility complex (MHC) congenic strains of nonobese diabetic (NOD) mice. The NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes.Semantic proximity Read ↗

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NOD mice and autoimmunity.Semantic proximity Read ↗

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A Hypermorphic Nfkbid Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8+ T Cells in NOD Mice.Semantic proximity Read ↗

MHC class I-mediated antigen presentation and induction of CD8+ cytotoxic T-cell responses in autoimmune diabetes-prone NOD mice.Semantic proximity Read ↗

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