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Article

Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling.

Genome biology - 1 Jan 2007

Liston Adrian, Hardy Kristine, Pittelkow Yvonne, Wilson Susan R, Makaroff Lydia E, Fahrer Aude M, Goodnow Christopher C

Abstract excerpt

BACKGROUND: T cells in the thymus undergo opposing positive and negative selection processes so that the only T cells entering circulation are those bearing a T cell receptor (TCR) with a low affinity for self. The mechanism differentiating negative from positive selection is poorly understood, d...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17239257
DOI: 10.1186/gb-2007-8-1-r12
PMCID: PMC1839132

Genes

AIRE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17239257-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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