Article

Strong selection of a few dominant CD8 clones in a TLR7-dependent autoimmune mouse model

2018-08-16

Abstract excerpt

Systemic lupus disease is characterized by the expansion of a self-reactive repertoire of B cells that, with the help of CD4 cells, generate IgG antibodies against common nuclear antigens. Meanwhile, the functional state and posible clonal selection of CD8 cells in lupus remain poorly defined. We previously described the activated but non-pathogenic phenotype of CD8 + T cells, some of which accumulate in the brai...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 36c6f634-b1e6-515a-819a-818049e75832
DOI: 10.1101/393819

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Strong selection of a few dominant CD8 clones in a TLR7-dependent autoimmune mouse modelDOI 10.1101/393819Read

Monogenic autoimmunity caused by TLR7 gain-of-functionSemantic proximity Read

B cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice.Semantic proximity Read

The endogenous repertoire harbors self-reactive CD4+ T cell clones that adopt a follicular helper T cell-like phenotype at steady state.Semantic proximity Read

TCRβ Sequencing Reveals Spatial and Temporal Evolution of Clonal CD4 T Cell Responses in a Breach of Tolerance Model of Inflammatory Arthritis.Semantic proximity Read

Humanized Mice Reveal New Insights Into the Thymic Selection of Human Autoreactive CD8+ T CellsSemantic proximity Read

TCRβ Sequencing Reveals Spatial and Temporal Evolution of Clonal CD4 T cell Responses in a Breach of Tolerance Model of Inflammatory ArthritisSemantic proximity Read

CD4+ virtual memory: Antigen-inexperienced T cells reside in the naïve, regulatory, and memory T cell compartments at similar frequencies, implications for autoimmunity.Semantic proximity Read

B cell-intrinsic TLR7 signaling is essential for the development of spontaneous germinal centers.Semantic proximity Read

TLR7 influences germinal center selection in murine SLE.Semantic proximity Read

Enhanced pathogenicity of diabetogenic T cells escaping a non-MHC gene-controlled near death experience.Semantic proximity Read

Nuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance.Semantic proximity Read

A Hypermorphic Nfkbid Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8+ T Cells in NOD Mice.Semantic proximity Read