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Article

Coexpression of p53 protein and MDR functional phenotype in leukemias: the predominant association in chronic myeloid leukemia.

Cytometry. Part B, Clinical cytometry - 1 Sept 2004

Cavalcanti Geraldo Barroso, Vasconcelos Flavia da Cunha, Pinto de Faria Giselle, Scheiner Marcos Antônio Maurício, de Almeida Dobbin Jane, Klumb Claudete Esteves, Maia Raquel C

Abstract excerpt

BACKGROUND: One of the best characterized resistance mechanisms of leukemias is multidrug resistance (MDR) mediated by P-glycoprotein (Pgp) and multidrug-resistant related protein (MRP). In addition to Pgp and MRP, p53 mutation or inactivation might play a relevant role in therapeutic failure. Some studies have demonstrated that Pgp and MRP may be activated in association with overexpression of mutant or...

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PMID: 15351976
DOI: 10.1002/cyto.b.20013

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Source receipt: pubmed, retrieved 7 Sept 2026.

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