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Article

Multidrug resistance in leukemia

1 Jan 1998

Abstract excerpt

Resistance of tumors to chemotherapeutic agents is an important factor that limits the successful treatment of a wide range of malignancies. The multidrug resistant (MDR) phenotype is well recognized in clinical samples, and it has been extensively studied, particularly in acute myeloid leukemia. One of the principle mechanisms underlying this MDR phenotype is the active cellular extrusion of chemotherapeutic...

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PMID: 9747635
DOI: 10.1097/00062752-199807000-00008

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