Article
Multidrug resistance in the chronic lymphoproliferative disorders.
Leukemia & lymphoma - 1 Oct 2010
Drain Stephen, Catherwood Mark A, Alexander H Denis
Abstract excerpt
Multidrug resistance (MDR) is a phenomenon in malignancy whereby tumor cells generate mechanisms to resist cytotoxic treatments. Several such mechanisms have been identified. However, to date the most significant research on MDR has involved the adenosine triphosphate binding cassette (ABC) transporter proteins, including P-glycoprotein (P-gp) and multidrug resistance associated protein (MRP). These proteins have...
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