Article
Subpopulations of normal peripheral blood and bone marrow cells express a functional multidrug resistant phenotype.
Blood - 1 Dec 1992
Drach D, Zhao S, Drach J, Mahadevia R, Gattringer C, Huber H, Andreeff M
Abstract excerpt
The multidrug-resistance gene, MDR1 is expressed in many normal tissues, but little is known about its expression in normal hematopoietic cells. Using the monoclonal antibody C219 and flow cytometric analysis, P-glycoprotein (P-gp) was found to be expressed in all peripheral blood (PB) subpopulat...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antigens, CD
- Bone Marrow
- Bone Marrow Cells
- Cell Line
- Doxorubicin
- Drug Resistance
- Fluorescent Antibody Technique
- Gene Expression
- Humans
- Leukemia, Myeloid, Acute
- Leukocytes
- Membrane Glycoproteins
- Multiple Myeloma
- Phenotype
- Polymerase Chain Reaction
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
- RNA, Messenger