P-glycoprotein and multidrug resistance-associated protein-1 expression in acute myeloid leukemia: Biological and prognosis implications.

doi:10.1111/ijlh.13241

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Article

P-glycoprotein and multidrug resistance-associated protein-1 expression in acute myeloid leukemia: Biological and prognosis implications.

International journal of laboratory hematology - 1 Oct 2020

da Silveira Júnior Lenilton Silva, Soares Victor de Lima, Jardim da Silva Alessandra Suelen, Gil Erica Aires, Pereira de Araújo Maria das Graças, Merces Gonçalves Ciro Alexandre, Paiva Aldair de Souza, Moura de Oliveira Taissa Maria, Oliveira Gustavo Henrique de Medeiros, Kramer Cavacanti E Silva Dany Geraldo, de Araújo Moura Lemos Telma Maria, Moretti Rebecchi Ivanise Marina, de Farias Sales Valeria Soraya, Luchessi André Ducati, Cavalcanti Júnior Geraldo Barroso

Abstract excerpt

BACKGROUND: Despite the advances in the cure rate for acute myeloid leukemia (AML), a considerable number of patients die from the disease due to the occurrence of multidrug resistance (MDR). Overexpression of the transporter proteins, such as P-glycoprotein (Pgp) and multidrug resistance-associated protein (MRP), confers resistance to the treatment of these leukemias. METHODS: To analyze the expression of the...

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PMID: 32452631
DOI: 10.1111/ijlh.13241

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