Article
Clinical significance of P-glycoprotein expression and function for response to induction chemotherapy, relapse rate and overall survival in acute leukemia.
Haematologica - 1 Jul 2000
Wuchter C, Leonid K, Ruppert V, Schrappe M, Büchner T, Schoch C, Haferlach T, Harbott J, Ratei R, Dörken B, Ludwig W D
Abstract excerpt
BACKGROUND AND OBJECTIVES: A multidrug-resistance (MDR) phenotype mediated by P-glycoprotein (P-gp) contributes to chemotherapy failure in acute leukemia. However, the exact prognostic significance of this resistance mechanism is still unclear, mostly due to methodologic problems in P-gp detection. We therefore investigated, whether P-gp expression levels or functional P-gp activity better predict response to...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Acute Disease
- Adolescent
- Adult
- Aged
- Bone Marrow Cells
- Child
- Child, Preschool
- Drug Resistance, Multiple
- Gene Expression
- Humans
- Infant
- Infant, Newborn