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Article

Contrasting features of MDR phenotype in leukemias by using two fluorochromes: implications for clinical practice.

Leukemia research - 1 Apr 2007

Vasconcelos Flavia C, Cavalcanti Geraldo B, Silva Karina L, de Meis Ernesto, Kwee Jolie K, Rumjanek Vivian M, Maia Raquel C

Abstract excerpt

The expression and activity of P-glycoprotein (Pgp) and multidrug resistance-associated protein (MRP1) were analyzed in 178 leukemia samples. Rhodamine-123 (Rho-123) and DiOC(2) were used as substrate to evaluate efflux pump activity. Chronic myeloid leukemia (CML) exhibited a higher percentage of positivity using Rho-123 than DiOC(2) (p=0.000) as compared to other types of leukemia. Moreover, Rho-123 was able to...

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Identifiers

PMID: 16979236
DOI: 10.1016/j.leukres.2006.07.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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