Article
Lack of correlation between expression and function of P-glycoprotein in acute myeloid leukemia cell lines.
Leukemia - 1 May 1995
Bailly J D, Muller C, Jaffrézou J P, Demur C, Gassar G, Bordier C, Laurent G
Abstract excerpt
In a panel of acute myeloblastic leukemia (AML) cell lines, representative of distinct differentiation stages, we investigated the possible correlation between drug-resistance and both expression and function of the multidrug resistance (MDR)-related P-glycoprotein (P-gp). The AML cell lines were KG1a, KG1, TF1, HEL, ML1, and two non drug-selected P-gp positive subclones originating from HL-60 (HL-60JD) and U937...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Acute Disease
- Cell Differentiation
- Coloring Agents
- Daunorubicin
- Drug Resistance
- Drug Screening Assays, Antitumor
- Flow Cytometry
- Gene Expression
- Humans