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Article

[Quantitative analysis of multidrug resistance phenotype in hematological malignancies].

Rinsho byori. The Japanese journal of clinical pathology - 1 Apr 1998

Kobayashi H, Takemura Y

Abstract excerpt

Cells with multidrug resistance (MDR) phenotype express P-glycoprotein (P-gp) on the cell membrane, which functions as a drug-efflux pump. To quantify the expression of the gene encoding P-gp (multidrug resistance 1; MDR1) and assess P-gp function, we developed competitive reverse transcription-polymerase chain reaction (RT-PCR) assay using heterologous competitor RNA and flow cytometric analysis using rhodamine...

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Identifiers

PMID: 9594630

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