Article
Evaluation of multidrug resistant phenotype by flow cytometry with monoclonal antibodies and functional tests.
Bulletin du cancer - 1 Mar 1995
Lizard G, Maynadié M, Roignot P, Lizard-Nacol S, Poupon M F
Abstract excerpt
Multidrug resistant (MDR) phenotype is characterized by a defect in drug accumulation caused by overexpression of a transmembrane glycoprotein, the P-glycoprotein (P-gp). MDR phenotype can be characterized either with monoclonal antibodies raised against P-gp or with functional tests, most often based on the incorporation of fluorescent compounds. In the present study, data obtained with the monoclonal antibodies...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antibodies, Monoclonal
- Antimetabolites, Antineoplastic
- Benzimidazoles
- Daunorubicin
- Drug Resistance, Multiple
- Flow Cytometry
- Fluorescent Antibody Technique
- Fluorescent Dyes
- Humans