Article
Polymorphism in the interleukin-10 promoter affects both provirus load and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis.
The Journal of infectious diseases - 1 Oct 2004
Sabouri Amir H, Saito Mineki, Lloyd Alun L, Vine Alison M, Witkover Aviva W, Furukawa Yoshitaka, Izumo Shuji, Arimura Kimiyoshi, Marshall Sara E F, Usuku Koichiro, Bangham Charles R M, Osame Mitsuhiro
Abstract excerpt
To investigate non-human leukocyte antigen candidate genes that influence the outcome of human T cell lymphotropic virus (HTLV) type I infection, we analyzed 6 single-nucleotide polymorphisms in the interleukin (IL)-10 promoter region in 280 patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and 255 HTLV-I-seropositive asymptomatic carriers from an area where HTLV-I is endemic. The...
Topics
- Alleles
- Gene Products, tax
- Human T-lymphotropic virus 1
- Interleukin-10
- Paraparesis, Tropical Spastic
- Polymorphism, Single Nucleotide
- Promoter Regions, Genetic
- Proviruses
- Risk
- Viral Load