Article
Polymorphisms in HTLV-1 Tax-responsive elements in HTLV-1-associated myelopathy/tropical spastic paraparesis patients are associated with reduced proviral load but not with disease progression.
The Journal of general virology - 1 Sept 2021
Gomes Yago Côrtes Pinheiro, Silva Marcus Tulius Teixeira, Leite Ana Claudia Celestino Bezerra, Lima Marco Antonio Sales Dantas, Araújo Abelardo Queiroz Campos, Silva Filho Isaac Lima, Vicente Ana Carolina Paulo, Espíndola Otávio de Melo
Abstract excerpt
Human T-lymphotropic virus type 1 (HTLV-1) provirus expression is mainly directed by Tax-responsive elements (TRE) within the long terminal repeats (LTR). Mutations in TRE can reduce provirus expression and since a high proviral load (PVL) is a risk factor for the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), we evaluated polymorphisms in the 5' LTR and the association with...
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