Article
Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10.
Proceedings of the National Academy of Sciences of the United States of America - 19 Dec 2000
Shin H D, Winkler C, Stephens J C, Bream J, Young H, Goedert J J, O'Brien T R, Vlahov D, Buchbinder S, Giorgi J, Rinaldo C, Donfield S, Willoughby A, O'Brien S J, Smith M W
Abstract excerpt
IL10 is a powerful TH-2 cell cytokine produced by lymphoid cells that limits HIV-1 replication in vivo, ostensibly by inhibiting macrophage/monocyte and T-cell lymphocyte replication and secretion of inflammatory cytokines (IL1, TNFalpha, IL6, IL8, and IL12). A genetic epidemiological scan of patients enrolled in AIDS cohorts for candidate gene-linked short tandem repeat polymorphisms revealed significant...
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