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Article

IL28B gene polymorphism SNP rs8099917 genotype GG is associated with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-1 carriers.

PLoS neglected tropical diseases - 1 Sept 2014

Assone Tatiane, de Souza Fernando Vieira, Gaester Karen Oliveira, Fonseca Luiz Augusto Marcondes, Luiz Olinda do Carmo, Malta Fernanda, Pinho João Renato Rebello, Gonçalves Fernanda de Toledo, Duarte Alberto Jose da Silva, de Oliveira Augusto Cesar Penalva, Casseb Jorge

Abstract excerpt

BACKGROUND: The polymorphisms of IL28B have been described as important in the pathogenesis of infections caused by some viruses. The aim of this research was to evaluate whether IL28B gene polymorphisms (SNP rs8099917 and SNP rs12979860) are associated with HAM/TSP. METHODS: The study included 229 subjects, classified according to their neurological status in two groups: Group I (136 asymptomatic HTLV-1...

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Share to HTLV-I Infections
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Share to Interferons
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Identifiers

PMID: 25233462
DOI: 10.1371/journal.pntd.0003199
PMCID: PMC4169378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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IL28B gene polymorphism SNP rs8099917 genotype GG is associated with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-1 carriers.PMID 25233462Read ↗

HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Is Not Associated with SNP rs12979860 of the IL-28B Gene.Semantic proximity Read ↗

HLA-G 3'-untranslated region polymorphisms are associated with HTLV-1 infection, proviral load and HTLV-associated myelopathy/tropical spastic paraparesis development.Semantic proximity Read ↗

Lack of evidence to support the association of a single IL28B genotype SNP rs12979860 with the HTLV-1 clinical outcomes and proviral load.Semantic proximity Read ↗

The influence of human leukocyte antigen class I loci -A, -B, -C, and class II HLA-DRB1 alleles in a Brazilian HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) population and association with disease outcome and proviral loadSemantic proximity Read ↗

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A Significant association between CXCL10 -1447 A>G and IL18 -607 C>A gene polymorphisms with Human T-cell lymphotropic virus type 1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM-TSP), a case-control report from city of Mashhad, IranSemantic proximity Read ↗

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