Article
Polygenic control of human T lymphotropic virus type I (HTLV-I) provirus load and the risk of HTLV-I-associated myelopathy/tropical spastic paraparesis.
The Journal of infectious diseases - 1 Oct 2002
Vine Alison M, Witkover Aviva D, Lloyd Alun L, Jeffery Katie J M, Siddiqui Asna, Marshall Sara E F, Bunce Mike, Eiraku Nobutaka, Izumo Shuji, Usuku Koichiro, Osame Mitsuhiro, Bangham Charles R M
Abstract excerpt
Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is one outcome of infection with HTLV-I. A population association study of 229 patients with HAM/TSP and 202 healthy carriers of HTLV-I in southern Japan showed that this outcome of HTLV-I infection and the HTLV-I provirus load are under polygenic control. Of 58 polymorphic sites studied in 39 non-HLA candidate...
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