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Article

Netrin-1 controls colorectal tumorigenesis by regulating apoptosis.

Nature - 2 Sept 2004

Mazelin Laetitia, Bernet Agnès, Bonod-Bidaud Christelle, Pays Laurent, Arnaud Ségolène, Gespach Christian, Bredesen Dale E, Scoazec Jean-Yves, Mehlen Patrick

Abstract excerpt

The expression of the protein DCC (deleted in colorectal cancer) is lost or markedly reduced in numerous cancers and in the majority of colorectal cancers due to loss of heterozygosity in chromosome 18q, and has therefore been proposed to be a tumour suppressor. However, the rarity of mutations found in DCC, the lack of cancer predisposition of DCC mutant mice, and the presence of other tumour suppressor genes in...

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Identifiers

PMID: 15343335
DOI: 10.1038/nature02788

Genes

DCC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Netrin-1 controls colorectal tumorigenesis by regulating apoptosis.PMID 15343335Read ↗

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The human tumor suppressor CEACAM1 modulates apoptosis and is implicated in early colorectal tumorigenesis.Semantic proximity Read ↗

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Defining the ligand specificity of the deleted in colorectal cancer (DCC) receptor.Semantic proximity Read ↗

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