DCC expression is altered by multiple mechanisms in brain tumours.

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Article

DCC expression is altered by multiple mechanisms in brain tumours.

Oncogene - 7 Dec 1995

Ekstrand B C, Mansfield T A, Bigner S H, Fearon E R

Abstract excerpt

The DCC (deleted in colorectal cancer) candidate tumor suppressor gene spans greater than 1350 kilobases at chromosomes 18q21.1 and encodes a transmembrane protein of unknown function. Although DCC is expressed in a number of adult tissues, its expression is highest in the brain and we have, ther...

Topics

Amino Acid Sequence
Animals
Base Sequence
Brain Neoplasms
Chromosome Deletion
Chromosomes, Human, Pair 18
DNA, Neoplasm
Genes, DCC
Glioblastoma
Heterozygote
Humans
Mice
Mice, Nude
Molecular Sequence Data
Mutation
Neoplasm Transplantation
Polymerase Chain Reaction
RNA Splicing

Source

Open in PubMed

Identifiers

PMID: 8570191

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8570191-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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