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Article

DCC expression is altered by multiple mechanisms in brain tumours.

Oncogene - 7 Dec 1995

Ekstrand B C, Mansfield T A, Bigner S H, Fearon E R

Abstract excerpt

The DCC (deleted in colorectal cancer) candidate tumor suppressor gene spans greater than 1350 kilobases at chromosomes 18q21.1 and encodes a transmembrane protein of unknown function. Although DCC is expressed in a number of adult tissues, its expression is highest in the brain and we have, therefore, undertaken studies to determine if DCC inactivation might contribute to tumors arising there. Decreased or...

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Source

Identifiers

PMID: 8570191

Genes

DCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DCC expression is altered by multiple mechanisms in brain tumours.PMID 8570191Read ↗

Role of the Dependence Receptor DCC in Colorectal Cancer PathogenesisSemantic proximity Read ↗

Identification of a chromosome 18q gene that is altered in colorectal cancers.Semantic proximity Read ↗

Mutation and expression of the DCC gene in human lung cancer.Semantic proximity Read ↗

Frequent loss of expression without sequence mutations of the DCC gene in primary gastric cancer.Semantic proximity Read ↗

The DCC gene: structural analysis and mutations in colorectal carcinomas.Semantic proximity Read ↗

Frequent allelic deletions and loss of expression characterize the DCC gene in male germ cell tumors.Semantic proximity Read ↗

Analysis of the DCC tumor suppressor gene in testicular germ cell tumors: mutations and loss of expression.Semantic proximity Read ↗

Expression and mutational analysis of the DCC, DPC4, and MADR2/JV18-1 genes in neuroblastoma.Semantic proximity Read ↗

The DCC Protein and Prognosis in Colorectal CancerSemantic proximity Read ↗

Association between schizophrenia and genetic variation in DCC: a case-control study.Semantic proximity Read ↗

Identification and characterization of neogenin, a DCC-related gene.Semantic proximity Read ↗

Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene.Semantic proximity Read ↗

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