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Article

The human tumor suppressor CEACAM1 modulates apoptosis and is implicated in early colorectal tumorigenesis.

Oncogene - 16 Dec 2004

Nittka Stefanie, Günther Juliane, Ebisch Cornelia, Erbersdobler Andreas, Neumaier Michael

Abstract excerpt

Defects in the adenomatous polyposis coli (APC) tumor suppressor pathway are sufficient for neoplastic transformation as the initiating step in colorectal carcinogenesis. In contrast, hyperplastic tumors possess normal APC function, and it is unclear whether they represent significant precursor lesion in cancer development. CEACAM1 is a tumor suppressor whose expression is known to be lost in the great majority...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15568039
DOI: 10.1038/sj.onc.1208259

Genes

CEACAM1
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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