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Article

Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Jan 1999

Meyerhardt J A, Caca K, Eckstrand B C, Hu G, Lengauer C, Banavali S, Look A T, Fearon E R

Abstract excerpt

Netrins, a family of laminin-related secreted proteins, have critical roles in axon guidance and cell migration during development. The deleted in colorectal cancer (DCC) protein has been implicated as a netrin-1 receptor component. The expression and function of netrins in adult tissues remain unknown, and direct interaction of netrin-1 with DCC has not been demonstrated. We cloned the human netrin-1 (NTN1L)...

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Identifiers

PMID: 9950216

Genes

DCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas.PMID 9950216Read ↗

Defining the ligand specificity of the deleted in colorectal cancer (DCC) receptor.Semantic proximity Read ↗

Role of the Dependence Receptor DCC in Colorectal Cancer PathogenesisSemantic proximity Read ↗

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Identification and characterization of neogenin, a DCC-related gene.Semantic proximity Read ↗

Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia.Semantic proximity Read ↗

Draxin Inhibits Axonal Outgrowth through the Netrin Receptor DCCSemantic proximity Read ↗

Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene.Semantic proximity Read ↗

Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer.Semantic proximity Read ↗

Netrin-1 controls colorectal tumorigenesis by regulating apoptosis.Semantic proximity Read ↗

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