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Article

Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer.

Gastroenterology - 1 Dec 2007

Shin Sung Kwan, Nagasaka Takeshi, Jung Barbara H, Matsubara Nagahide, Kim Won Ho, Carethers John M, Boland C Richard, Goel Ajay

Abstract excerpt

BACKGROUND & AIMS: DCC and UNC5C, Netrin-1 dependence receptors, perform an important role in intestinal epithelial biology. Both receptors frequently are down-regulated in colorectal cancer (CRC). Although CRCs frequently lose DCC owing to deletions at 18q, the mechanism for the UNC5C loss is poorly understood. We hypothesized that UNC5C is silenced epigenetically in CRC, and that there are interactions between...

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Source

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Identifiers

PMID: 18054557
DOI: 10.1053/j.gastro.2007.08.074
PMCID: PMC4139066

Genes

DCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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