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Article

DCC constrains tumour progression via its dependence receptor activity.

Nature - 11 Dec 2011

Castets Marie, Broutier Laura, Molin Yann, Brevet Marie, Chazot Guillaume, Gadot Nicolas, Paquet Armelle, Mazelin Laetitia, Jarrosson-Wuilleme Loraine, Scoazec Jean-Yves, Bernet Agnès, Mehlen Patrick

Abstract excerpt

The role of deleted in colorectal carcinoma (DCC) as a tumour suppressor has been a matter of debate for the past 15 years. DCC gene expression is lost or markedly reduced in the majority of advanced colorectal cancers and, by functioning as a dependence receptor, DCC has been shown to induce apoptosis unless engaged by its ligand, netrin-1 (ref. 2). However, so far no animal model has supported the view that the...

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Source

Identifiers

PMID: 22158121
DOI: 10.1038/nature10708

Genes

DCC
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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