Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice.

Molecular and cellular biology - 1 Sept 2004

Hulit James, Wang Chenguang, Li Zhiping, Albanese Chris, Rao Mahadev, Di Vizio Dolores, Shah Salimuddin, Byers Stephen W, Mahmood Radma, Augenlicht Leonard H, Russell Robert, Pestell Richard G

Abstract excerpt

Constitutive beta-catenin/Tcf activity, the primary transforming events in colorectal carcinoma, occurs through induction of the Wnt pathway or APC gene mutations that cause familial adenomatous polyposis. Mice carrying Apc mutations in their germ line (ApcMin) develop intestinal adenomas. Here, the crossing of ApcMin with cyclin D1-/- mice reduced the intestinal tumor number in animals genetically heterozygous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli Protein
Share to beta Catenin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin D1

Share to Gastrointestinal Neoplasms

Share to Intestinal Mucosa

Share to Intestinal Polyps

Share to Receptors, Cytoplasmic and Nuclear

Source

Open in PubMed Open full text

Identifiers

PMID: 15314168
DOI: 10.1128/MCB.24.17.7598-7611.2004
PMCID: PMC507010

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice.PMID 15314168Read ↗

Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine.Semantic proximity Read ↗

Targeted inactivation of the p21(WAF1/cip1) gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosal.Semantic proximity Read ↗

Targeting phospholipase D1 attenuates intestinal tumorigenesis by controlling β-catenin signaling in cancer-initiating cellsSemantic proximity Read ↗

Dietary calcium and cholecalciferol modulate cyclin D1 expression, apoptosis, and tumorigenesis in intestine of adenomatous polyposis coli1638N/+ mice.Semantic proximity Read ↗

Inhibition of Intestinal Polyposis with Reduced Angiogenesis in ApcMin/+ Mice Due to Decreases in c-Myc ExpressionSemantic proximity Read ↗

Period 2 mutation accelerates ApcMin/+ tumorigenesis.Semantic proximity Read ↗

TMIGD1, a putative tumor suppressor, induces G2-M cell cycle checkpoint arrest in colon cancer cellsSemantic proximity Read ↗

Tgfbr1 Haploinsufficiency Is a Potent Modifier of Colorectal Cancer DevelopmentSemantic proximity Read ↗

Differential Regulation of D-Type Cyclins in the Mouse IntestineSemantic proximity Read ↗

A Targeted Constitutive Mutation in the Apc Tumor Suppressor Gene Underlies Mammary But Not Intestinal TumorigenesisSemantic proximity Read ↗

Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis in miceSemantic proximity Read ↗

Myc heterozygosity attenuates the phenotypes of APC deficiency in the small intestine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.