Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The adenomatous polyposis coli tumor suppressor and Wnt signaling in the regulation of apoptosis.

Advances in experimental medicine and biology - 1 Jan 2009

Benchabane Hassina, Ahmed Yashi

Abstract excerpt

The adenomatous polyposis coli (APC) tumor suppressor is an essential negative regulator in the evolutionarily conserved Wnt/Wingless (Wg) signal transduction pathway. During normal development, Wnt signaling is required not only to induce cell proliferation and cell fate specification, but also to induce apoptotic cell death. However in some malignant states triggered by APC loss, inappropriate activation of Wnt...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli Protein
Share to Apoptosis
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to Genes, APC

Share to Liver Neoplasms

Share to Signal Transduction

Share to Wnt Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19928354
DOI: 10.1007/978-1-4419-1145-2_7
PMCID: PMC3066060

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The adenomatous polyposis coli tumor suppressor and Wnt signaling in the regulation of apoptosis.PMID 19928354Read ↗

Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene.Semantic proximity Read ↗

Dual positive and negative regulation of wingless signaling by adenomatous polyposis coli.Semantic proximity Read ↗

Exploiting APC Function as a Novel Cancer TherapySemantic proximity Read ↗

Apoptosis and APC in colorectal tumorigenesis.Semantic proximity Read ↗

Biology of the adenomatous polyposis coli tumor suppressor.Semantic proximity Read ↗

Wnt-Independent and Wnt-Dependent Effects of APC Loss on the Chemotherapeutic ResponseSemantic proximity Read ↗

The APC tumor suppressor promotes transcription-independent apoptosis in vitro.Semantic proximity Read ↗

The ABC of APC.Semantic proximity Read ↗

Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epithelia.Semantic proximity Read ↗

Caspase cleavage of the APC tumor suppressor and release of an amino-terminal domain is required for the transcription-independent function of APC in apoptosis.Semantic proximity Read ↗

Adenomatous polyposis coli in cancer and therapeutic implicationsSemantic proximity Read ↗

[Familial adenomatous polyposis syndrome (FAP): pathogenesis and molecular mechanisms].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.