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Article

Netrin-1, a missing link between chronic inflammation and tumor progression

1 Apr 2010

Abstract excerpt

Netrin-1 discovered as a neuronal navigation cue, has been recently proposed to play a crucial role during colorectal tumorigenesis by regulating apoptosis. This survival activity is mediated via the inhibition of the so-called netrin-1 dependence receptors. The netrin-1 receptors, DCC (for Deleted in Colorectal Cancer) and UNC5H (UNC5 homologues), indeed belong to the functional family of dependence receptors...

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PMID: 20305387
DOI: 10.4161/cc.9.7.11072

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