Article
Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene.
Nature - 24 Apr 1997
Fazeli A, Dickinson S L, Hermiston M L, Tighe R V, Steen R G, Small C G, Stoeckli E T, Keino-Masu K, Masu M, Rayburn H, Simons J, Bronson R T, Gordon J I, Tessier-Lavigne M, Weinberg R A
Abstract excerpt
The DCC (Deleted in colorectal cancer) gene was first identified as a candidate for a tumour-suppressor gene on human chromosome 18q. More recently, in vitro studies in rodents have provided evidence that DCC might function as a receptor for the axonal chemoattractant netrin-1. Inactivation of th...
Topics
- Animals
- Axons
- Brain
- Brain Neoplasms
- Cell Adhesion Molecules
- Cell Division
- Chimera
- Chromosome Mapping
- Colorectal Neoplasms
- DCC Receptor
- Gene Targeting
- Genes, DCC
- Humans
- Intestinal Mucosa
- Intestinal Neoplasms