Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of cell motility by tyrosine phosphorylated villin.

Molecular biology of the cell - 1 Nov 2004

Tomar Alok, Wang Yaohong, Kumar Narendra, George Sudeep, Ceacareanu Bogdan, Hassid Aviv, Chapman Kenneth E, Aryal Ashish M, Waters Christopher M, Khurana Seema

Abstract excerpt

Temporal and spatial regulation of the actin cytoskeleton is vital for cell migration. Here, we show that an epithelial cell actin-binding protein, villin, plays a crucial role in this process. Overexpression of villin in doxycyline-regulated HeLa cells enhanced cell migration. Villin-induced cell migration was modestly augmented by growth factors. In contrast, tyrosine phosphorylation of villin and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to CSK Tyrosine-Protein Kinase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytoskeleton

Share to Microfilament Proteins

Share to Protein-Tyrosine Kinases

Share to Pyrimidines

Share to src-Family Kinases

Share to Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 15342783
DOI: 10.1091/mbc.e04-05-0431
PMCID: PMC524729

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of cell motility by tyrosine phosphorylated villin.PMID 15342783Read ↗

Obligatory role for phospholipase C-gamma(1) in villin-induced epithelial cell migration.Semantic proximity Read ↗

Serines in the Intracellular Tail of Podoplanin (PDPN) Regulate Cell MotilitySemantic proximity Read ↗

An actin-binding site containing a conserved motif of charged amino acid residues is essential for the morphogenic effect of villin.Semantic proximity Read ↗

Noonan syndrome/leukemia-associated gain-of-function mutations in SHP-2 phosphatase (PTPN11) enhance cell migration and angiogenesis.Semantic proximity Read ↗

A role for VICKZ proteins in the progression of colorectal carcinomas: regulating lamellipodia formationSemantic proximity Read ↗

The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization.Semantic proximity Read ↗

Integrin-linked kinase regulates migration and proliferation of human intestinal cells under a fibronectin-dependent mechanism.Semantic proximity Read ↗

SEPT9_v4 expression induces morphological change, increased motility and disturbed polarity.Semantic proximity Read ↗

Phosphorylation of GMFγ by c-Abl coordinates lamellipodial and focal adhesion dynamicsSemantic proximity Read ↗

Functional dissection and molecular characterization of calcium-sensitive actin-capping and actin-depolymerizing sites in villin.Semantic proximity Read ↗

The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells.Semantic proximity Read ↗

Tyrosine phosphorylation of VE-cadherin prevents binding of p120- and beta-catenin and maintains the cellular mesenchymal state.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.