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Article

Functional dissection and molecular characterization of calcium-sensitive actin-capping and actin-depolymerizing sites in villin.

The Journal of biological chemistry - 22 Oct 2004

Kumar Narendra, Tomar Alok, Parrill Abby L, Khurana Seema

Abstract excerpt

All proteins of the villin superfamily, which includes the actin-capping and -severing proteins such as gelsolin, scinderin, and severin, are calcium-regulated actin-modifying proteins. Like some of these proteins, villin has morphologically distinct effects on actin assembly depending on the free calcium concentrations. At physiological calcium (Ca2+) villin nucleates and bundles actin, whereas at higher...

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PMID: 15272027
DOI: 10.1074/jbc.M405424200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional dissection and molecular characterization of calcium-sensitive actin-capping and actin-depolymerizing sites in villin.PMID 15272027Read ↗

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