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Article

Serines in the Intracellular Tail of Podoplanin (PDPN) Regulate Cell Motility

26 Mar 2013

Abstract excerpt

Podoplanin (PDPN) is a transmembrane receptor that affects the activities of Rho, ezrin, and other proteins to promote tumor cell motility, invasion, and metastasis. PDPN is found in many types of cancer and may serve as a tumor biomarker and chemotherapeutic target. The intracellular region of PDPN contains only two serines, and these are conserved in mammals including mice and humans. We generated cells from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23530051
DOI: 10.1074/jbc.c112.446823

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