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Article

Integrin-linked kinase regulates migration and proliferation of human intestinal cells under a fibronectin-dependent mechanism.

Journal of cellular physiology - 1 Feb 2010

Gagné David, Groulx Jean-François, Benoit Yannick D, Basora Nuria, Herring Elizabeth, Vachon Pierre H, Beaulieu Jean-François

Abstract excerpt

Integrin-linked kinase (ILK) plays a role in integrin signaling-mediated extracellular matrix (ECM)-cell interactions and also acts as a scaffold protein in functional focal adhesion points. In the present study, we investigated the expression and roles of ILK in human intestinal epithelial cells (IECs) in vivo and in vitro. Herein, we report that ILK and its scaffold-function interacting partners, PINCH-1,...

Topics

Actinin
Adaptor Proteins, Signal Transducing
Caco-2 Cells
Cell Differentiation
Cell Movement
Cell Proliferation
Cell Shape
DNA-Binding Proteins
Enterocytes
Fibronectins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Humans

Intestines

LIM Domain Proteins

Membrane Proteins

Microfilament Proteins

Phenotype

Protein Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 19885839
DOI: 10.1002/jcp.21963
PMCID: PMC2814089

Genes

ILK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Integrin-linked kinase regulates migration and proliferation of human intestinal cells under a fibronectin-dependent mechanism.PMID 19885839Read ↗

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