Article
SEPT9_v4 expression induces morphological change, increased motility and disturbed polarity.
The Journal of pathology - 1 Aug 2005
Chacko Alex D, Hyland Paula L, McDade Simon S, Hamilton Peter W, Russell Se Hilary, Hall Peter A
Abstract excerpt
Several lines of evidence indicate that altered expression of SEPT9 is seen in human neoplasia. In particular there is evidence of altered expression of the SEPT9_v4 isoform. The functional consequences of this remain unclear. We have studied the expression of wild-type- and GTP-binding mutants (G144V and S148N) of the SEPT9_v4 isoform in the MCF7 cell line as a model for its deregulation in neoplasia. We find...
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