The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells.

doi:10.1074/jbc.273.40.25770

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Article

The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells.

The Journal of biological chemistry - 2 Oct 1998

Huang C, Liu J, Haudenschild C C, Zhan X

Abstract excerpt

Cortactin, a filamentous actin cross-linking protein and a substrate of Src protein tyrosine kinase, is phosphorylated at tyrosine residues upon stimulation by extracellular signals. We have previously demonstrated that the filamentous actin cross-linking activity of cortactin is attenuated by Sr...

Topics

Actins
Amino Acid Sequence
Animals
Cell Line
Cell Movement
Cortactin
Endothelium, Vascular
Epitopes
Fluorescent Antibody Technique
Humans
Mice
Microfilament Proteins
Molecular Sequence Data
Mutation
Phosphopeptides
Phosphorylation
Phosphotyrosine
Sequence Analysis

Source

Open in PubMed

Identifiers

PMID: 9748248
DOI: 10.1074/jbc.273.40.25770

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9748248-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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