Article
Noonan syndrome/leukemia-associated gain-of-function mutations in SHP-2 phosphatase (PTPN11) enhance cell migration and angiogenesis.
The Journal of biological chemistry - 9 Jan 2009
Wang Siying, Yu Wen-Mei, Zhang Wanming, McCrae Keith R, Neel Benjamin G, Qu Cheng-Kui
Abstract excerpt
Mutations in SHP-2 phosphatase (PTPN11) that cause hyperactivation of its catalytic activity have been identified in Noonan syndrome and various childhood leukemias. Recent studies suggest that the gain-of-function (GOF) mutations of SHP-2 play a causal role in the pathogenesis of these diseases. However, the molecular mechanisms by which GOF mutations of SHP-2 induce these phenotypes are not fully understood....
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