Article
Association of a novel single nucleotide polymorphism in the human perforin gene with the outcome of HTLV-I infection in patients from northeast Iran (Mash-had).
Human immunology - 1 Aug 2004
Rafatpanah Houshang, Pravica Vera, Farid Reza, Abbaszadegan Mohammed Reza, Tabatabaei Abbas, Goharjoo Abbas, Etemadi Mohammed Mehdi, Hutchinson Ian V
Abstract excerpt
Human T lymphotropic virus I (HTLV-I)-specific cytotoxic T lymphocytes (CTL) recognize the products of the HTLV-I Tax, in the context of HLA-A2 and kill their target through a perforin-dependent mechanism. The efficiency of the CTL response may lead HTLV-I-infected individuals to remain carriers or to the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Perforin is a cytolytic...
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