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Article

Analyses of HTLV-1 sequences suggest interaction between ORF-I mutations and HAM/TSP outcome.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Nov 2016

Barreto Fernanda Khouri, Khouri Ricardo, Rego Filipe Ferreira de Almeida, Santos Luciane Amorim, Castro-Amarante Maria Fernanda de, Bialuk Izabela, Pise-Masison Cynthia A, Galvão-Castro Bernardo, Gessain Antoine, Jacobson Steven, Franchini Genoveffa, Alcantara Luiz Carlos

Abstract excerpt

The region known as pX in the 3' end of the human T-cell lymphotropic virus type 1 (HTLV-1) genome contains four overlapping open reading frames (ORF) that encode regulatory proteins. HTLV-1 ORF-I produces the protein p12 and its cleavage product p8. The functions of these proteins have been linked to immune evasion and viral infectivity and persistence. It is known that the HTLV-1 infection does not necessarily...

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Identifiers

PMID: 27553711
DOI: 10.1016/j.meegid.2016.08.020
PMCID: PMC5123959

Genes

HBZ

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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