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Article

Novel polymorphisms in the promoter region of the perforin gene among distinct Brazilian populations and their functional impact.

International journal of immunogenetics - 1 Jun 2014

Garcia F B, Kashima S, Rodrigues E S, Silva I T, Malta T M, Nicolete L D de Figueiredo, Haddad R, Moraes-Souza H, Covas D T

Abstract excerpt

Cytotoxic T lymphocytes and natural killer cells play a crucial role in eliminating tumour and virus-infected cells. The perforin is a key part of the arsenal that these cells use to destroy their targets. In this study, we characterized single-nucleotide polymorphisms (SNPs) located in the promoter region of the perforin gene among distinct Brazilian ethnic groups. The study was carried out by sequencing this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24321052
DOI: 10.1111/iji.12103

Genes

PRF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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