Genome wide association study of HTLV-1-associated myelopathy/tropical spastic paraparesis in the Japanese population.

doi:10.1073/pnas.2004199118

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Article

Genome wide association study of HTLV-1-associated myelopathy/tropical spastic paraparesis in the Japanese population.

Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 2021

Penova Marina, Kawaguchi Shuji, Yasunaga Jun-Ichirou, Kawaguchi Takahisa, Sato Tomoo, Takahashi Meiko, Shimizu Masakazu, Saito Mineki, Tsukasaki Kunihiro, Nakagawa Masanori, Takenouchi Norihiro, Hara Hideo, Matsuura Eiji, Nozuma Satoshi, Takashima Hiroshi, Izumo Shuji, Watanabe Toshiki, Uchimaru Kaoru, Iwanaga Masako, Utsunomiya Atae, Tabara Yasuharu, Paul Richard, Yamano Yoshihisa, Matsuoka Masao, Matsuda Fumihiko

Abstract excerpt

HTLV-1-associated myelopathy (HAM/TSP) is a chronic and progressive inflammatory disease of the central nervous system. The aim of our study was to identify genetic determinants related to the onset of HAM/TSP in the Japanese population. We conducted a genome-wide association study comprising 753 HAM/TSP patients and 899 asymptomatic HTLV-1 carriers. We also performed comprehensive genotyping of HLA-A, -B, -C,...

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PMID: 33649182
DOI: 10.1073/pnas.2004199118
PMCID: PMC7980450

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