Article
Acetyl-CoA carboxylase alpha gene and breast cancer susceptibility.
Carcinogenesis - 1 Dec 2004
Sinilnikova Olga M, Ginolhac Sophie M, Magnard Clémence, Léoné Mélanie, Anczukow Olga, Hughes David, Moreau Karen, Thompson Deborah, Coutanson Christine, Hall Janet, Romestaing Pascale, Gérard Jean-Pierre, Bonadona Valérie, Lasset Christine, Goldgar David E, Joulin Virginie, Venezia Nicole Dalla, Lenoir Gilbert M
Abstract excerpt
The identification of an interaction between BRCA1 and acetyl-CoA carboxylase alpha (ACCalpha), a key enzyme in lipid synthesis, led us to investigate the role of ACCalpha in breast cancer development, where it might contribute to the energy-sensing mechanisms of malignant transformation. In order to investigate if certain ACCalpha alleles may be high-risk breast cancer susceptibility alleles, 37 extended breast...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.