Article
Inhibin alpha-subunit (INHA) expression in adrenocortical cancer is linked to genetic and epigenetic INHA promoter variation.
PloS one - 1 Jan 2014
Hofland Johannes, Steenbergen Jacobie, Voorsluijs Jacoba M, Verbiest Michael M P J, de Krijger Ronald R, Hofland Leo J, de Herder Wouter W, Uitterlinden Andre G, Feelders Richard A, de Jong Frank H
Abstract excerpt
Adrenocortical carcinoma (ACC) is a rare, but highly malignant tumor of unknown origin. Inhibin α-subunit (Inha) knockout mice develop ACCs following gonadectomy. In man, INHA expression varies widely within ACC tissues and its circulating peptide inhibin pro-αC has been described as a novel tumor marker for ACC. We investigated whether genetic and epigenetic changes of the INHA gene in human ACC cause loss or...
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