Article

Rare and Potentially Pathogenic Variants in Hydroxycarboxylic Acid Receptor Genes Identified in Breast Cancer Cases.

2020-10-05

Abstract excerpt

<title>Abstract</title> <p>BackgroundThree genes, clustered together on chromosome 12, comprise a group of Hydroxycarboxylic Acid Receptors (HCARs), <italic>HCAR1</italic>, <italic>HCAR2</italic>, and <italic>HCAR3</italic>. These paralogous genes encode different G-protein coupled receptors that are responsible for detecting glycolytic metabolites and controlling fatty acid oxidation. Though better known for reg...

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Literature Corpus work: 84bd7baf-3264-5e8b-8fa0-27044c3b772e
DOI: 10.21203/rs.3.rs-61768/v1

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