Article
Haplotype-based analysis of common variation in the acetyl-coA carboxylase alpha gene and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 2007
Sinilnikova Olga M, McKay James D, Tavtigian Sean V, Canzian Federico, DeSilva Deepika, Biessy Carine, Monnier Stéphanie, Dossus Laure, Boillot Catherine, Gioia Lydie, Hughes David J, Jensen Majken K, Overvad Kim, Tjonneland Anne, Olsen Anja, Clavel-Chapelon Françoise, Chajès Véronique, Joulin Virginie, Linseisen Jakob, Chang-Claude Jenny, Boeing Heiner, Dahm Stephan, Trichopoulou Antonia, Trichopoulos Dimitrios, Koliva Maria, Khaw Kay-Tee, Bingham Sheila, Allen Naomi E, Key Timothy, Palli Domenico, Panico Salvatore, Berrino Franco, Tumino Rosario, Vineis Paolo, Bueno-de-Mesquita H Bas, Peeters Petra H, van Gils Carla H, Lund Eiliv, Pera Guillem, Quirós José Ramón, Dorronsoro Miren, Martínez García Carmen, Tormo María-José, Ardanaz Eva, Hallmans Goran, Lenner Per, Berglund Göran, Manjer Jonas, Riboli Elio, Lenoir Gilbert M, Kaaks Rudolf
Abstract excerpt
A key fatty acid synthesis enzyme, acetyl-CoA carboxylase alpha (ACC-alpha), has been shown to be highly expressed in human breast cancer and other tumor types and also to specifically interact with the protein coded by one of two major breast cancer susceptibility genes BRCA1. We used a comprehensive haplotype analysis to examine the contribution of the ACC-alpha common genetic variation (allele frequency >5%)...
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