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Article

Functional single-nucleotide polymorphism in acetyl-CoA carboxylase ACACB gene promoter.

DNA and cell biology - 1 Dec 2010

Lee Alex K, Kyriakou Theodosios, Weston Andrew J, O'Dell Sandra D

Abstract excerpt

The acetyl-CoA carboxylase isoform ACC2 expressed in the liver generates malonyl-CoA, which primarily regulates fatty acid oxidation through inhibition of the mitochondrial carrier carnitine palmitoyl-CoA transferase-I. Activity is initiated by sterol regulatory element-binding protein-1 (SREBP-1) binding to steroid response elements SRE in ACACB gene promoter P-II. We proposed that sequence variation in the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20799892
DOI: 10.1089/dna.2010.1078

Genes

ACACB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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